Nephrosis

Aminonucleoside Nephrosis

Experimental renal disease was produced in young rats by daily subcutaneous injections of 6-dimethylamino purine, 3-amino-d-ribose (aminonucleoside). The physiologic, biochemical, and light microscopic changes were similar to those observed in human nephrosis. Electron microscopy of the glomeruli from animals which received seven or more daily injections of aminonucleoside revealed characterist...

A.C.T.H. in nephrosis.

During the past two years 16 cases of nephrosis have been treated with cortisone and/or A.C.T.H. (adrenocorticotrophin) at this hospital. The results of cortisone treatment have been reported previously (Arneil and Wilson, 1952) and corresponding findings for A.C.T.H. are now given and the value of the two hormones compared. The criteria used when including a patient in this investigation and t...

Hetastarch-induced osmotic nephrosis.

A 63-YR-OLD male (weighing approximately 83 kg) with no significant past medical history underwent an open reduction and internal fixation of his femur fracture under general anesthesia. He had been nil per os for 14 h and his preoperative blood pressure was 136/74 mmHg. Intraoperative course was uneventful, except for a 5–7 min episode of relative hypotension with systolic pressures 80 – 85 mm...

Cortisone treatment of nephrosis.

The accepted picture of the nephrotic syndrome is that of a grossly oedematous patient with massive albuminuria but having no hypertension or azotaemia. The amount of albumin circulating in the plasma is greatly reduced, resulting in a fall in the total protein content and a reversal of the albumin/ globulin ratio. The cholesterol content of the blood is markedly raised. Little is known of the ...

Immunological studies in congenital nephrosis.